Dimethyl Sulfoxide
Apexbio Technology LLC Veliparib dihydrochloride 912445-05-7 10mM (in 1mL DMSO)
Veliparib dihydrochloride (CAS 912445-05-7) is a selective inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 enzymes responsible for DNA repair processes frequently upregulated in various cancers Veliparib inhibits PARP1 and PARP2 with K(i) values of 5 2 and 2 9 nmol/L respectively In colon cancer cell lines (HCT-116 HT-29) veliparib enhances DNA damage and induces G2/M arrest when combined with SN38 or oxaliplatin In preclinical murine melanoma (B16F10) breast cancer (MX-1) and colon cancer (HCT-116) xenografts combination therapy with DNA-damaging agents shows improved antitumor effects
Apexbio Technology LLC PD184352 (CI-1040) 212631-79-3 10mM (in 1mL DMSO)
PD184352 (CI-1040 CAS 212631-79-3) is a benzhydroxamate derivative that selectively inhibits the MEK1/2 kinases members of the MAP kinase kinase (MAPKK) family It interacts with a hydrophobic pocket adjacent to the Mg-ATP binding region of MEK1/2 triggering conformational shifts that favor the inactive non-phosphorylated state of these enzymes Acting via an ATP- and ERK1/2-independent inhibitory mechanism PD184352 robustly suppresses purified MEK1 enzyme activity (IC50 17 nM) Preclinical research demonstrates efficacy in reducing tumor growth notably in murine xenograft models of colon carcinoma underscoring its utility as a research tool in oncology
Apexbio Technology LLC PF-477736 952021-60-2 10mM (in 1mL DMSO)
PF-477736 is an ATP-competitive small-molecule inhibitor of checkpoint kinase 1 (Chk1) It selectively inhibits Chk1 kinase activity demonstrating nanomolar inhibitory potency in kinase assays and exhibits lower affinity toward related kinases such as CDK1 and Chk2 In vitro studies utilizing human cancer cell lines show PF-477736 disrupts Chk1-dependent G2-phase cell-cycle arrest induced by DNA-damaging agents preferentially targeting tumor cells with compromised p53 function while minimizing cytotoxicity to normal cells PF-477736 is widely utilized experimentally to study DNA damage response mechanisms potential chemosensitizing effects and therapeutic implications for cancers harboring p53 mutations
Apexbio Technology LLC BV6 1001600-56-1 10mM (in 1mL DMSO)
BV6 (CAS 1001600-56-1) is a selective inhibitor targeting the inhibitor of apoptosis protein (IAP) family The IAP family includes proteins such as XIAP c-IAP1 and c-IAP2 that regulate programmed cell death pathways BV6 induces apoptosis and sensitizes cancer cells to chemotherapeutic agents and radiation by decreasing expression levels of IAPs including XIAP and c-IAP1 In vitro treatment with BV6 exhibited an IC50 of 7 2 M in H460 non-small cell lung carcinoma cells and enhanced their response to radiation BV6 is employed in research exploring cancer cell apoptosis modulation and therapeutic resistance
Apexbio Technology LLC SBI-0206965 1884220-36-3 10mM (in 1mL DMSO)
SBI-0206965 (CAS 1884220-36-3) is a small-molecule inhibitor targeting ULK1 (UNC-51-like kinase 1) a serine/threonine kinase pivotal in regulating autophagy initiation ULK1 functions downstream of mTORC1 and is modulated by AMPK influencing cellular responses to nutrient deprivation In cellular assays using A549 cells SBI-0206965 at 5 mM effectively suppresses AZD8055-induced autophagy and increases apoptotic response upon nutrient starvation in MEFs U87MG glioblastoma and mouse lung cancer cell lines SBI-0206965 serves as a useful research tool for investigating autophagy pathways tumor cell survival and apoptosis mechanisms
Apexbio Technology LLC JNK-IN-8 1410880-22-6 10mM (in 1mL DMSO)
JNK-IN-8 (CAS 1410880-22-6) is a potent and specific inhibitor of c-Jun N-terminal kinase (JNK) isoforms JNK1 JNK2 and JNK3 It functions by forming a covalent bond with a conserved cysteine residue in JNKs inducing conformational alteration in the kinase activation loop consequently impairing substrate binding Its IC50 values for JNK1 JNK2 and JNK3 are 4 67 nM 18 7 nM and 0 98 nM respectively In cellular assays JNK-IN-8 prevention of c-Jun phosphorylation demonstrates robust selectivity towards the JNK signaling pathway thus making it valuable as a research tool in studying stress-related cellular responses and apoptosis
Apexbio Technology LLC Sodium Picosulfate 10040-45-6 10mM (in 1mL DMSO)
Sodium picosulfate is an organic stimulant laxative widely utilized to investigate bowel motility and electrolyte balance Its pharmacological activity involves inhibition of fluid and electrolyte absorption alongside enhancement of their secretion in the intestinal lumen thus promoting bowel evacuation In vitro studies evaluating human rat and rabbit liver cell cultures showed sodium picosulfate interaction with hepatic cells notably rabbit hepatocytes demonstrated higher sensitivity reflected by decreased cellular protein content at concentrations in the g/ml range Clinical research supports the utility of sodium picosulfate in experimental constipation models including drug-induced and chronic constipation settings allowing assessment of bowel function and symptoms such as abdominal distension and stool consistency
Apexbio Technology LLC Mesoridazine(Synonyms: Serentil, Mesoridazine besylate, TPS-23), 10mM (in 1mL DMSO), CAS: 5588-33-0.
Mesoridazine (CAS 5588-33-0) is a dopaminergic antagonist primarily targeting dopamine D2 receptors (K d 19 nM) As an active metabolite of the atypical antipsychotic thioridazine mesoridazine demonstrates marked inhibitory effects on both pre- and postsynaptic dopamine receptors impacting dopamine and acetylcholine neurotransmission Furthermore mesoridazine engages histamine H1 (K d 1 8 nM) muscarinic acetylcholine (K d 69 nM) 1-adrenergic (K d 2 nM) and 2-adrenergic (K d 1600 nM) receptors Its receptor profile makes mesoridazine valuable for neuroscience research into antipsychotic mechanisms and neurotransmitter regulation
Med Vet International Chorion (Hcg) 10,000 IU, 5X10mL, Vet Label
VET LICENSE NEEDS TO BE PROVIDED IN 3-4 BUSINESS DAYS OR ORDER WILL BE CANCELLED
Chorion (HCG) 10, 000 IU, 5X10ml, Vet Label
Apexbio Technology LLC Pracinostat (SB939) 929016-96-6 10mM (in 1mL DMSO)
Pracinostat (SB939 CAS 929016-96-6) is an orally bioavailable inhibitor of histone deacetylases (HDAC) preferentially targeting class I II and IV HDACs with substantially lower affinity for class III enzymes By inhibiting these enzymes pracinostat promotes accumulation of acetylated histone H3 and acetylated -tubulin subsequently upregulating cell cycle regulator p21 In preclinical investigations SB939 demonstrated antiproliferative activity in various tumor cell lines including colon ovarian prostate cancers acute myeloid leukemia (AML) and B-cell lymphoma highlighting its potential utility in oncology research
Apexbio Technology LLC Fludarabine(Synonyms: Fludarabine Phosphate, Fludara, Fludarabinum, 2-Fluoro-ara-AMP, 9H-Purin-6-amine), 10mM (in 1mL DMSO), CAS: 21679-14-1.
Fludarabine (CAS 21679-14-1) is a purine analog prodrug that inhibits DNA synthesis Upon cellular uptake it undergoes phosphorylation to its active triphosphate form (F-ara-ATP) disrupting DNA replication through inhibition of critical enzymes such as DNA primase DNA ligase I ribonucleotide reductase and DNA polymerases and In human myeloma RPMI8226 cell assays fludarabine suppressed cell growth reduced Akt phosphorylation and lowered anti-apoptotic proteins XIAP and Survivin In vivo studies demonstrated marked tumor growth inhibition in RPMI8226 xenograft models Fludarabine serves as a tool in oncology research particularly leukemia and multiple myeloma-related studies
Apexbio Technology LLC BIRB 796 (Doramapimod) 285983-48-4 10mM (in 1mL DMSO)
BIRB 796 (Doramapimod CAS 285983-48-4) is a potent inhibitor of human p38 mitogen-activated protein kinase (MAPK) which modulates the signaling pathways associated with inflammatory cytokine production It demonstrates significant inhibition of TNF- release (EC50 18 nM) in THP-1 cells In animal models oral administration reduces LPS-induced TNF- synthesis and ameliorates collagen-induced arthritis severity Clinically however trials for Crohn s disease showed no superiority over placebo BIRB 796 serves as a valuable research tool in inflammation and cytokine signaling studies
Selleck Chemical LLC Trametinib DMSO solvate S4484-25mg
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis
Cayman Chemical DMSO asy Reagent 1mL
A DPP-9 inhibitor (IC50 0.0034 UM) selective for DDP-9 over DPP-8 DPP-4 DPP-2 FAP and prolyl endopeptidase (IC50s 0.6 >10 >5 10 and >10 UM respectively) induces LDH release from THP-1 and HL-60 leukemia cells at 10 UM